![]() ![]() This is hypothesized to cause an excess of synaptic pruning in the brain during the postnatal period ( 10).ĭifferent approaches have been used to study common and rare genetic causes of schizophrenia and have contributed to advancement in the understanding of the biology of the disorder. ![]() The strongest GWAS finding specifically for schizophrenia was the association with genetic markers across the Major Histocompatibility Complex (MHC) locus on chromosome 6 and the C4 gene. An etiological overlap between major psychiatric disorders have been found with common genetic variations in neuronal, immune and histone pathways. CNVs tend to be expressed in the developing brain suggesting a common neurodevelopmental origin for many psychiatric disorders indicating that primary prevention would need to start in childhood ( 8, 9). ![]() It is important to explain clearly that CNVs and SNVs may be inherited or they may occur de novo and that CNVs predispose to a variety of psychiatric disorders with limited diagnostic specificity. The aim is to identify the genetic influences on mental disorders and rare single-nucleotide variants (SNVs) have been associated with schizophrenia and other psychiatric disorders ( 7). It includes investigation of polygenic mechanisms and examination of copy number variants (CNVs) and potential clinical applications for polygenic risk scores that calculate the joint contribution of common variants. There has been a lot of progress in psychiatric genetics due to genome-wide association studies (GWAS) with the focus on identifying the underlying biological mechanisms contributing to disease. Some of the important findings to take into consideration will be summarized here, without going into specific gene, receptor or molecular details. Specific details about the exact gene, receptor or neurotransmitter involved are not required during the process of PGC, but the information should be detailed enough for a patient or family to make an informed decision about genetic testing. Discussion Genetic influences in the development of schizophrenia Based on this presentation, the aim of this perspective article is to summarize some of the important findings regarding the genetics of schizophrenia and to provide a brief guide for the general psychiatrist on implementation of PGC in clinical practice. To better equip psychiatrists in training for future encounters where families or patients ask questions related to the genetics of schizophrenia, a postgraduate presentation was prepared as part of the academic program at the University of Pretoria. Psychiatrists regularly have to answer questions about heritability, genetic risks and the role of genetic testing in diagnosis or treatment selection ( 6). Professional education is needed to better prepare psychiatrists to provide PGC in a manner that will assist patients and families to better understand the genetics of schizophrenia ( 5). Due to the complexity of psychiatric disorders PGC is among the most challenging topics encountered in clinical practice. It is expected that more people will seek PGC as technological and scientific advances enable more precise identification of individual genetic risks. Psychiatric genetic counseling (PGC) is a minor sub-specialty of genetic counseling that is not routinely provided for psychiatric conditions and there is a lack of consensus about the best way to deliver it to patients ( 4). The challenge psychiatrists face is the translation of the genetic findings into clinical practice to improve the lives of patients and families. There has been steady progress in the field of psychiatric genetics, generating new and fascinating insight into the genetic and phenotypic complexity of mental illness ( 3).Īdvances in psychiatric genetics has unraveled the genetic architecture of mental illness. This combination of genes do not fully control the risk of developing a mental illness and is dependent on the interaction with non-genetic factors ( 2). Vulnerability to a mental illness is a genetically complex trait that emerges from the interaction of multiple genes. The identification of genes that contribute to the risk of developing a mental disorder and influence the course of the illness is the goal of molecular genetic studies in the field. It was expected that gene discovery will transform clinical psychiatric practice, but the genetics of mental illness have been found to be enormously complex ( 2). It is well-established that the risk of schizophrenia and many other mental illnesses runs in families with adoption, twin and family studies pointing to a heredity transmission of risk. Genetic and environmental factors contribute to the susceptibility of an individual to develop schizophrenia ( 1). Major psychiatric disorders, including schizophrenia are complex, polygenic disorders. ![]()
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![]() ![]() Following: Content from all accounts a user follows ![]() However, if you open Instagram hourly, the app tries to show you the most relevant content you haven’t seen before. If you open Instagram once daily, you see the posts that Instagram’s algorithm feels are the most relevant for that day. Frequency: How often a user opens InstagramĮvery time a user opens up the app, the Instagram algorithm tries to show the best posts since their last visit. To determine who your best friends are, Instagram’s algorithm studies your past interactions to see which accounts you engage with most often.Īn Instagram spokesperson also told Business Insider that profile searches are a signal Instagram looks at when ranking posts in your feed. This implies that content from your “best friends” likely rank higher on your feed. Instagram doesn’t want you to miss important posts from your friends and family, such as a post about your friend’s engagement. Relationship: The accounts you regularly interact with For example, if you scroll through your Instagram timeline at 11 pm and then check it again at 9 am the next morning, Instagram would only sort the posts created in between your check-ins. Instagram wants to show you posts that are recent and, consequently, more relevant.Īccording to a talk from Instagram’s Thomas Dimson, the Instagram algorithm re-orders only the new posts between your current visit and your last visit. The next key ingredient in the Instagram algorithm is timeliness. Posts with less engagement that are more relevant to you can still appear right at the top of your feed. So, if there’s a certain genre of content that you engage with more frequently (e.g., food), Instagram might rank content in that genre (e.g., food, restaurants, etc.) higher on your feed.Īn Instagram spokesperson told Business Insider that ranking of Instagram posts is not a popularity contest. Instagram looks at your past activity to gauge your potential interest. “The order of photos and videos in your feed will be based on the likelihood you’ll be interested in the content, your relationship with the person posting and the timeliness of the post.” ![]() When the algorithmic timeline was announced, Instagram mentioned that it shows you content that you’re likely to be interested in first: Interest: How much Instagram predicts you’ll care about a post Instagram revealed there are six factors that determine what you see in your Instagram feed: interest, timeliness, relationship, frequency, following, and usage. The Instagram Explore page works in the same way - it looks at the accounts you have interacted with before and uses those interactions to suggest content it thinks you might enjoy.īut the Instagram algorithm considers so much more than that. If you’re wondering why there always seems to be a new Instagram algorithm, it’s because the algorithm uses machine learning to customize what shows up in each person’s Instagram feed. How does the Instagram algorithm work? The 6 key ranking factors In this post, we’ll dig into the factors that influence the Instagram algorithm and share tips for increasing your chances of getting your content on more people’s Instagram timelines. The question is - how does Instagram determine which content meets that criteria? The Instagram algorithm was introduced to help surface the best, most relevant content to each user every time they check their Instagram feed. A marketer's approach to sharing content in the IG feed.Answers to Instagram's frequently-asked algorithm questions.The most important ranking factors of the Instagram algorithm.We’ll go through the factors that influence the ranking of your content and explain why the Instagram algorithm is actually great for marketers. We’ll break down the Instagram feed for you. ![]() ![]() ![]() You dedicate so much space in the book to people who inspired and helped you – your ‘guardian angels.’ What was it like to reflect so deeply again on all those relationships? ‘You’ve gotta read this’: The books Globe staffers are loving this week And she just released her clear-eyed new memoir, Don’t Tell Anybody the Secrets I Told You, in which she shares intimate thoughts and details about her childhood, her craft, her “guardian angels” and – endearingly – her myriad crushes. She just announced a new record, Stories from a Rock n Roll Heart (June 30), featuring appearances by Bruce Springsteen, Margo Price and Angel Olsen. She has a packed touring schedule, with a stop in Vancouver slated for August. Since healing from her November, 2020, stroke, the indomitable country-rock singer/songwriter Lucinda Williams, who turned 70 in January, has been back at it in a major way. ![]() Just scan your diapers and wipes into the Pampers Club app and turn them into Pampers Cash.Please log in to bookmark this story. Once your baby is sound asleep, take some time to earn cash for all your Pampers purchases. In fact, singing them a lullaby is one of the tips! In the meantime, check out this article on newborn sleep to learn more about your baby’s sleeping needs and to discover ways to soothe them when they’re crying. We hope these lullaby ideas inspire you to warm up your vocal cords and maybe even create your own baby lullaby. But by no means are you limited to these selections. They can create a wonderful bonding moment as well as help your baby go to sleep. Still wondering what is a good lullaby to sing to your baby? Singing any of these lullabies for babies or bedtime songs to your little one at nighttime are good options. The incomparable Julie Andrews (as the novice and governess Maria) sings to the von Trapp children:Īnd the moon, is the only, light we'll see In these uncertain times, “My Favorite Things” gives hope to little ones that all will be well as long as there’s hope. With impending war and uncertainty, the film offers an uplifting view of life, love, and happiness despite hardship, and this song couldn’t underline that message any better. The story follows Austrian widower Georg von Trapp and his family as they take on a new governess who intends to become a nun. That’s the message of “My Favorite Things,” written and composed by Rodgers and Hammerstein for The Sound of Music. When times are bad or sad, think about all the things that make you happy. The bright blessed day, the dark sacred nightĪnd I think to myself what a wonderful world. ![]() Listen to Doris Day’s original recording:Īnd I think to myself what a wonderful world. Feel free to swap out the gender if you’re singing to your little boy. And it provides a great lesson about life, i.e., “whatever will be, will be.” The catchy melody makes it easy to sing. It couldn’t be a better lullaby for a child who’s filled with wonder. Each verse of the song progresses through the life of an inquisitive child (in this case, the singer) who asks their mother questions about life and love. The song went on to win an Academy Award, became Day’s signature song, and was recorded by countless artists thereafter. “Que Sera, Sera (Whatever Will Be, Will Be)”įirst introduced in 1955, “Que Sera, Sera” was made famous a year later by Doris Day in Alfred Hitchcock’s film The Man Who Knew Too Much. Till by turning, turning we come ’round right. 'Twill be in the valley of love and delight. ![]() 'Tis the gift to come down where we ought to be,Īnd when we find ourselves in the place just right, 'Tis the gift to be simple, ’tis the gift to be free Thanks to Copland, we have this beautiful tune with touching lyrics that make the perfect lullaby. He later released the song in 1950 as part of a set in Old American Songs. “Simple Gifts”īased on a Shaker tune from 1848, “Simple Gifts” wasn’t very well known outside of the Shaker community until composer Aaron Copland used the melody in his Appalachian Spring, which premiered in 1944. The winds of night so softly are sighing, It fills the sails of boats that are waiting, ![]() ![]() ![]() Xmplify uses its knowlege of your document's current structure and its definition (DTD or XML Schema) to provide intelligent auto-completion suggestions. The verification results are automatically kept up to date as your edit your document.Īuto-complete XML based on its DTD or XML Schema ![]() If your document specifies a DTD or XML Schema, Xmplify automatically uses that to verify your document's content. Xmplify provides an Outline view of your document that shows its structure, and automatically keeps the Outline up to date to reflect the latest edits. See your document's structure at a glance Xmplify analyses your XML as you type, and maintains a rich set of meta-data so it can provide intelligent editing aids and suggestions according to your document's content and the current editing context. Xmplify XML Editor is a native Mac app built from the ground up for Mac OS X, and provides a number of powerful features to make working with and manipulating XML simple and intuitive: via java.exe -jar saxon-he-10.5.jar -xsl:searchScript.xsl -s:input.xml -o:output.xml and within searchScript.xsl provide a simple XSLT that will copy any found element to output.xml and add the XPath to the search result (if that's too big, just remove location=""), e.g.Xmplify HomePage | RecentChanges | EditorIndex | TextEditorFamilies | Preferences You shall change the Workbench setting editor options > max file size to 40MB so your file will be nicely rendered and then load your XML file into the XML editor and trigger XPath based search.įYI, Saxon is rather fast in my experience, so it may be worth to create an XSLT for searching. Even if you cannot name all hierarchy levels but need w:* somewhere, it's most likely still much faster.įYI, notepad++ with XML Plugin also offers limited XPath support, so you may try that one.įYI, if you have access to an inubit installation (because it's an enterprise service bus / business process engine it is only licensed by organisations like companies but not individuals), it is IMHO worth a shot. by providing an absolute XPath like /w:document/w:body/w:p/w:r/w:t/w:inst this would most likely speed up your search massively. If you could narrow down which elements could be relevant, e.g. One major factor is that your XPath is starting with // so every XML element of the whole document will be checked for the predicate you gave - it is the same as if you wrote /descendant-or-self::*. Feel free to migrate if there’s a better Stack for it. I debated whether to post this here or on StackOverflow, but since I’m specifically not doing this programmatically, I decided this was probably the better place. ![]() What is the reason for this? Why is XPath (apparently) so resource-intensive? Does it differ between OSes (mine is macOS Sierra)? The other applications I’ve tried using were not as egregiously bad, but opening the document and running any kind of XPath query still took minutes, and their memory usages were countable in GB too, so it’s not just Xmplify being inefficient. That seems rather excessive to me for a single XPath query in a single file, even if it is a fairly big file. After about 15 minutes of going at around 100% CPU, Xmplify was now using 60 GB of memory, and my OS was telling me that I had run out of application memory and needed to start force-quitting stuff. Then I tried to perform this XPath query (I’m looking for all tracked insertions consisting of the string en): //w:ins That took about three minutes, and with no other documents open Xmplify’s memory usage rose to about 1 GB. I’ve tried with Xmplify, QXmlEdit, SublimeText with the XPath extension, etc., and they all suffer from the same problem: just opening the file is ridiculously slow and hogs an awful lot of memory, and doing an XPath search is nigh impossible.Īs an example, I just tried opening the file in Xmplify. I’m doing this ‘manually’ rather than programmatically, by opening the file in an XML editor and searching there. I have a large XML file (about 37 MB-it’s the underlying XML file in a Word document of about 350 pages) that I am trying to search through with XPath. ![]() ![]() ![]() In addition to getting phone numbers for individual users, it's also possible to search and acquire toll or toll free phone numbers for services such as Audio Conferencing (for conference bridges), auto attendants, and call queues. Toll and toll free phone numbers for services The country/region is based on the location of the user's license in the Microsoft 365 admin center > Active Users and not the billing address listed under the Organization Profile in the Microsoft 365 admin center. You can also see Assign, change, or remove a phone number for a user. To find those phone numbers, go to Getting phone numbers for your users. But for your users, after you assign a Calling Plan to them, you can assign a user phone number so they can make and receive phone calls. See Getting service phone numbers to get phone numbers. In addition to getting phone numbers for individual users, it's also possible to search and acquire toll or toll free phone numbers for services such as Audio Conferencing (for conference bridges), auto attendants and call queues. The availability of toll phone numbers from some of these locations might vary at any given time depending on inventory levels. To place and receive calls, Phone System users use their mobile devices, a headset with a laptop or PC, or one of many IP phones that work with Teams. Phone System users click a name in their address book, and Teams will place a call to that person. When you add a Calling Plan for users, they can use Teams to take care of basic call-control tasks, such as placing and receiving calls, transferring calls, and muting and unmuting calls. With Phone System, you create auto attendants and call queues (with a toll or toll free number) to answer incoming calls for your organization. For those users, you'll need to Set up Communications Credits for your organization. Unfortunately, we can't control this behavior, and as a result, your experience may vary depending on the toll free number dialed and the restrictions of the toll free number.ĭialing out from a meeting to another country/region in the world that isn't listed below is available using Communication Credits. The ability to dial out to toll free numbers varies widely depending on the restrictions of the toll free number dialed. For example, if you dial out from the United States to a toll free number in Brazil, the call may not be successful because the call didn't originate from within Brazil or from a specific region within Brazil. Dedicated toll and toll free numbers can be assigned to your organization from additional cities.ĭialing out to toll free or free phone numbers may not be possible, because some toll free numbers only function from within a certain country or area within a country. Toll numbers from the following countries or regions are automatically assigned as shared audio conferencing numbers to organizations when they're enabled for Audio Conferencing. With Audio Conferencing, there are toll and toll free phone numbers that can be used by your users to dial in to meetings. When you've decided that you want Audio Conferencing for your organization, buy one Audio Conferencing license for each person in your organization who is going to schedule/host an audio meeting. ![]() Teams includes the Audio Conferencing feature for just this situation! People can call in to meetings using a phone instead of using the Teams apps on a mobile device or PC. Sometimes people in your organization will need to use a phone to call in to a meeting. Want to learn more about these services Audio Conferencing If you need to get more telephone numbers for your users, see Getting phone numbers for your users or, for phone number request forms, Manage phone numbers for your organization. After you've verified if one of the Teams services is available, you can see Microsoft Teams add-on licensing to help you buy licenses and assign them to your users. ![]() ![]() ![]()
![]() They are also the creator the game’s sequel, Afterlife: The Game. You’ll only need your mouse, so don’t worry about the keyboard.Join millions of players from around the. Play online in your browser on PC, Mobile and Tablet devices. Players can play the game anytime, anywhere, without downloading it. Gacha Life is a free online game provided by Lagged. You don’t have much time for each minigame, so make it count! Gacha Life is free to play online on all of the available platforms.Rainbow Melody: Put your memory to test by repeating the right sequence of notes on your xylophone.Travel Puzzles: Assemble colorful blocks of different shapes and unravel the captured photo underneath.Study Session: Tap away every distraction to show everyone how actual studying is done.Burger Madness: Drag the delicious ingredients on a plate, stack them in the correct order and make the best burgers in town. Star your gacha life with dress up To create your character you have the buttons on the left of the blank slate, and they represent: For each of these items you have multiple options to pick from, so change them up as much as you like, maybe even combine them in new ways never seen before, and were sure you will create a really interesting.Handcraft your very own anime-inspired stories in Gacha Life by Lunime, now playable on now.gg. ![]() What are the newest mini games in Life the Game? Play Gacha Life online for free with now.gg mobile cloud. ![]() You can play Life: The Game for free, but your bad decisions might cost you your in-game survival! Join thousands of Life: The Game online players and cycle through tons of fun minigames! How to play Life - The Game? As of 2020, there are four new fun mini games: Burger Madness, Study Session, Travel Puzzles & Rainbow Melody. Gacha Life is a mix of dressing and life simulator where you can design your hero from scratch and choose what fate awaits him or her. This Life game features different minigames for each stage of your life. Gacha Life Online is one of those games where you get to create your own story and design all the characters who star in it. Life: The Game on Poki is the best way to experience an entire journey, from birth to death, in game form! From study dates to actual dates, play Life: The Game and see if your life is delightful or disastrous. ![]() ![]() ![]() ![]() Yes, you won't be breaking any Instagram rule!Īs I said before, all that happens is, your caption's line breaks get replaced by a new invincible character.ĭon't worry about you getting banned or anything similar, this will never be the cause. Once you click "Copy", your text is obviously going to be copied to your clipboard.īut, before that, we take every space or line break that you have created, and convert it to a Space Separator Unicode Character called "Thin Space."Ī little bit more about "Thin Space" is that it was added to Unicode in version 1.1 (1993), and it belongs to the block General Punctuation in the Basic Multilingual Plane. Other websites will never share what they do with your text and how everything works, we think that's shady and you deserve to know what's going on in the background. We never see your text, and we never will, it all happens in your device you have full privacy over what you type. This means that you can exit the page and come back later, and everything is still going to be here for you unless you intentionally clear it.Īside from that, as you might have noticed, there is no sign up required! We also use your own browser to store your text as you type. This tool has been made for you to have the best user experience at all times.įor example, when clicking the "Clear" button, we present you with a double-confirmation prompt, so that you don't lose your text by mistake. Why use this tool over other alternatives out there? Instead of using dots, or emojis, now you have a clean space between your content and your hashtags. So, just paste your caption with your hashtags, or your first comment, and hit enter as many times as you want. Whether you put them in your captions or your first comment, hashtags are not aesthetically pleasing in your audience's timelines! What other uses does this tool have?Īnother useful thing that you can do with this tool is hide your hashtags. So use it for that too whenever you need it. That will automatically convert and copy the entire text, so the next thing that you would need to do is paste it wherever you want.Īside from captions, this also works in comments and bios as well! Step 3: Press or click on "Copy"Īfter you are happy with your caption, just tap or click on "Copy." We do this so that you don't have to spend time going back to our website just because Instagram rejected your caption saying it was too long. You can leave as many line breaks as you wish! They will all stay.Īlso, our tool will automatically tell you how many characters your text has in comparison to Instagram's character limit, which is 2200 characters. ![]() ![]() Step 2: Format it exactly how you want it to lookĪfter you have typed or pasted your text, just make sure to format it exactly how you want it to look on Instagram. The first thing that you should do is either type your text directly or paste it if you already have it. Let me show you how to use it! Step 1: Paste or type your text in the text area This simple tool can easily solve that for you. Instagram has never made it easy for creators to directly create line breaks on their captions. Have you tried to separate your paragraphs on Instagram just to find out that they always get together after you save your changes? ![]() ![]() ![]() The three flashing red lights and the well known Red Ring of Death was a common inconvenience for the owners. The early builds of the Xbox 360 had many hardware failures caused by overheating. Each company released their consoles based on various strategies to attract the gamer. The seventh-generation came in 2005, with Sega out of the hardware market, and now the market is all about the-all-known-three companies, Sony, Nintendo, and Microsoft. ![]() You can still buy the original Xbox 360 from Amazon. Many other exclusive titles followed like Ninja Gaiden, Fable and Tom Clancy’s Splinter Cell: Chaos Theory, which helped a lot the franchise to succeed. One of the biggest hits for Xbox was Halo, a science fiction first-person shooter game, developed by Bungie, with smooth and balanced gameplay followed with its sequel in 2004 were more-than-enough reasons to buy an Xbox. It was the time were Xbox Live launched and Microsoft offered to players a unique, steady and reliable online experience, but only with a subscription. Xbox was the first console to have a built-in Ethernet port, combined with a broadband connection. Microsoft engineers originally called the console “ DirectX Box“, named after the DirectX graphics technology, that was developed for PC gaming and later was shortened to Xbox. This led Xbox to use the PC’s x86 architecture, a build that was very rare for a console at the time. The console’s prototype was put together at first as a side project, using Dell laptop parts and then Microsoft decided to redesign it. They proved everyone wrong by selling 550,000 units of hardware in its first week. At the time, the sixth-generation console market was overwhelmed by PlayStation 2, GameCube and Dreamcast, leading Microsoft to rise through a very competitive marketplace, and people were wondering if the Xbox console would be an expensive mistake. The original Xbox, Microsoft debuted in the home console gaming market, with a characteristic big size in black and green colors, was released on November 15, 2001. You can still buy the original Xbox from Amazon. ![]() ![]() His guilt has festered for three years without an outlet. The more mundane explanations are that he blames himself for her death, which is not unusual: he was seconds late to stop the killers from murdering both his wife and his daughter.
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